Simultaneous detection of attomolar pathogen DNAs by Bio-MassCode mass spectrometryf

Bing Yang; Kai Gu; Xiaoru Sun; Huan Huang; Yibing Ding; Fuqiang Wang; Guohua Zhou; Lequn Lee Huang

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Simultaneous detection of attomolar pathogen DNAs by Bio-MassCode mass spectrometryf

机译：通过Bio-MassCode质谱同时检测attomolar病原体DNA f

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A general method is described to analyze pathogen DNAs in homogenous solution by a novel Bio-MassCode probe, using a small organic (namely disulfide) "reporter mass" that self-assembled in oligonucleotide-modified gold nanoparticles. With conventional MALDI TOF MS, the assay simultaneously detected DNAs for HIV, HBV, HCV, and TP with extraordinarily high sensitivity in the low attomolar (10~(-18) M) range without any other amplification.

机译：描述了一种通过使用新型的Bio-MassCode探针在均质溶液中分析病原体DNA的通用方法，该方法使用在寡核苷酸修饰的金纳米颗粒中自组装的小的有机（即二硫化物）“报告分子”。使用常规MALDI TOF MS，该检测方法可以同时检测HIV，HBV，HCV和TP的DNA，并且在低分子（10〜（-18）M）范围内具有极高的灵敏度，而无需任何其他扩增。

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来源
《Chemical Communications》 |2010年第43期|p.8288-8290|共3页
作者
Bing Yang; Kai Gu; Xiaoru Sun; Huan Huang; Yibing Ding; Fuqiang Wang; Guohua Zhou; Lequn Lee Huang;
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作者单位

Institute of Molecular Medicine and School of Medicine,Nanjing University, Nanjing 210093, China;

School of Chemistry and Chemical Engineering, Nanjing University,Nanjing 210093, China;

rnInstitute of Molecular Medicine and School of Medicine,Nanjing University, Nanjing 210093, China;

rnLaboratory of Molecular Diagnostics, Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, China;

Institute of Molecular Medicine and School of Medicine,Nanjing University, Nanjing 210093, China;

rnNanjing Medical University, Laboratory of Reproductive Medicine,Department of Histology and Embryology, Nanjing, China;

rnInstitute of Molecular Medicine and School of Medicine,Nanjing University, Nanjing 210093, China Laboratory of Molecular Diagnostics, Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, China;

Institute of Molecular Medicine and School of Medicine,Nanjing University, Nanjing 210093, China;

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入库时间 2022-08-17 13:24:25

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Simultaneous detection of attomolar pathogen DNAs by Bio-MassCode mass spectrometryf

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