Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence

Anass Znabet; Job Zonneveld; Elwin Janssen; Frans J. J. De Kanter; Madeleine Helliwell; Nicholas J. Turner; Eelco Ruijter; Romano V. A. Orru

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Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence

机译：串联生物催化/ Ugi / Pictet-Spengler型环化序列的合成生物碱的不对称合成

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We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds.

机译：我们将3,4-顺式取代的中吡咯烷的生物催化去对称化与Ugi型多组分反应相结合，然后在原位采用Pictet-Spengler型环化反应序列进行快速非对称合成生物碱样多环化合物。

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《Chemical Communications》 |2010年第41期|p.7706-7708|共3页
作者
Anass Znabet; Job Zonneveld; Elwin Janssen; Frans J. J. De Kanter; Madeleine Helliwell; Nicholas J. Turner; Eelco Ruijter; Romano V. A. Orru;
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Department of Chemistry & Pharmaceutical Sciences,Vrije Universiteit Amsterdam, De Boelelaan 1083,1081 HV Amsterdam, The Netherlands;

rnDepartment of Chemistry & Pharmaceutical Sciences,Vrije Universiteit Amsterdam, De Boelelaan 1083,1081 HV Amsterdam, The Netherlands;

rnDepartment of Chemistry & Pharmaceutical Sciences,Vrije Universiteit Amsterdam, De Boelelaan 1083,1081 HV Amsterdam, The Netherlands;

rnDepartment of Chemistry & Pharmaceutical Sciences,Vrije Universiteit Amsterdam, De Boelelaan 1083,1081 HV Amsterdam, The Netherlands;

rnSchool of Chemistry, University of Manchester, Brunswick Street,Manchester, UK M13 9PL;

School of Chemistry, University of Manchester, ManchesterInter-disciplinary Biocentre, 131 Princess Street, Manchester,UK M1 7DN;

rnDepartment of Chemistry & Pharmaceutical Sciences,Vrije Universiteit Amsterdam, De Boelelaan 1083,1081 HV Amsterdam, The Netherlands;

rnDepartment of Chemistry & Pharmaceutical Sciences,Vrije Universiteit Amsterdam, De Boelelaan 1083,1081 HV Amsterdam, The Netherlands;

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Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence

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