Flavin-cyclodextrin conjugates as catalysts of enantioselective sulfoxidations with hydrogen peroxide in aqueous media

摘要

β-Cyclodextrin-flavin conjugates are highly efficient catalysts for the sulfoxidation of methyl phenyl sulfides with hydrogen peroxide in neat aqueous media operating at loadings down to 0.2 mol% and allowing for enantioselectivities up to 80% ee.rnEnantiomerically pure sulfoxides are important chiral auxiliaries employed in asymmetric syntheses as well as active substances used in the pharmaceutical chemistry. Enantioselective sulfoxidation of prochiral sulfides thus represents one of the key transformations in organic synthesis.