Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4

Susanna Cogoi; Luigi E. Xodo

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Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4

机译：5,10,15,20（N-丙基-4-吡啶基）卟啉（TPrPyP4）的增强的G4-DNA结合：与TMPyP4的比较研究

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The cationic porphyrin TPrPyP4, with four propyl substituents in the pyridinium rings, is evaluated in vitro by spectroscopic and polymerase-stop assays as a G4-DNA ligand and in cultured cells as a modulator of gene transcription. A comparison with the widely used TMPyP4 is presented.

机译：阳离子卟啉TPrPyP4在吡啶鎓环中具有四个丙基取代基，在体外通过光谱和聚合酶终止试验作为G4-DNA配体，在培养的细胞中作为基因转录的调节剂进行了评估。提出了与广泛使用的TMPyP4的比较。

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《Chemical Communications》 |2010年第39期|p.7364-7366|共3页
作者
Susanna Cogoi; Luigi E. Xodo;
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Department of Biomedical Science and Technology, University of Udine, 33100 Udine, Italy;

rnDepartment of Biomedical Science and Technology, University of Udine, 33100 Udine, Italy;

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4. Novel porphyrin dyes with enhanced light absorption and binding strength for dye-sensitized solar cells [C] . Liping Si, Wenhui Li, Zhixin Zhao National Meeting Exhibition . 2013

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5. In vitro DNA-binding studies of cyclic AMP responsive element binding protein and CCAAT/enhancer binding protein beta. [D] . Popova, Katerina. 2004

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6. TMPyP4 Porphyrin Distorts RNA G-quadruplex Structures of the Disease-associated r(GGGGCC)n Repeat of the C9orf72 Gene and Blocks Interaction of RNA-binding Proteins [O] . Bita Zamiri, Kaalak Reddy, Robert B. Macgregor Jr., 2014

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7. Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): a comparative study with TMPyP4 [O] . COGOI S, XODO L 2010

机译：5,10,15,20（N-丙基-4-吡啶基）卟啉（TPrPyP4）的增强的G4-DNA结合：与TMPyP4的比较研究

Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4

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