Highly efficient catalase activity of metallocorroles

摘要

The iron(III) complex of a bipolar and amphiphilic corrole, which binds strongly to proteins and undergoes protein-mediated cellular uptake, catalyzes the decomposition of hydrogen peroxide faster (k_(cat) = 6400 M~(-1) s~(-1)) and more efficiently (turnover frequency > 120 s~(-1)) than previously reported synthetic compounds with catalase-like activity.rnSuperoxide anion radical (O_2~(·-) ), constantly produced during normal cellular metabolism, is the primary source of many reactive oxygen species (ROS).