Manganese displacement from Zinpyr-1 allows zinc detection by fluorescence microscopy and magnetic resonance imaging

摘要

A paramagnetic manganese complex of a ttuorescein-based probe affords a dual-modality zinc sensor featuring an improved fluorescence dynamic range and an MRI readout.rnSeveral metal-based receptors have been employed in displacement assays to detect biologically relevant analytes, such as carbonate, phosphate, and nitric oxide. In optical sensors that provide a fluorescence readout, the emissive reporter is typically quenched by coordination of a paramagnetic metal ion, which is displaced by the analyte to provide an increase in emission intensity.