Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block

摘要

A short and enantioselective de novo synthesis of an L-glycero-D-ntanno-heptose building block for the total synthesis of a Yersinia pestis cell wall polysaccharide is described.rnThe plague is re-emerging as cases have been reported in more than 20 countries in Africa and Asia. Yersinia pestis is the causative agent of the plague, an infection of rodents accidentally transmitted to humans by the bite of infected fleas. The disease is manifested in bubonic and pneumonic forms and constitutes a potential bioterrorism threat. The need for vaccines against Yersinia pestis is becoming urgent.