Antibody-functionalized SERS tags with improved sensitivity

摘要

Protein detection at the femtomolar level can be achieved by using metallic nanoparticle assemblies that function as surface enhanced Raman spectroscopy reporters and that contain suitable surface-bound recognition elements. Proper control of the interaction between nanoparticles within the assemblies is critical for achieving this performance. Innovative biosensory approaches based on the properties of colloidal nanoparticle (NP) assemblies have emerged with the potential to reach single-molecule detection thresholds.1'2