Rational design of a Tn antigen mimicf

Francisco Corzana; Jesus H. Busto; Filipa Marcelo; Marisa Garcia de Luis; Juan L. Asensio; Sonsoles Martin-Santamaria; Yolanda Saenz; Carmen Torres; Jesus Jimenez-Barbero; Alberto Avenoza; Jesus M. Peregrina

首页> 外文期刊>Chemical Communications >Rational design of a Tn antigen mimicf

【24h】

Rational design of a Tn antigen mimicf

机译：Tn抗原模拟物的合理设计

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.

机译：报道了一种新型的Tn抗原模拟物，其中天然的基础氨基酸已被非天然的α-甲基丝氨酸类似物替代。该衍生物对天然凝集素表现出与天然Tn相似的亲和力，并保留了使用抗MUC1抗体在含Tn的糖肽中观察到的生物活性构象。

著录项

来源
《Chemical Communications》 |2011年第18期|p.5319-5321|共3页
作者
Francisco Corzana; Jesus H. Busto; Filipa Marcelo; Marisa Garcia de Luis; Juan L. Asensio; Sonsoles Martin-Santamaria; Yolanda Saenz; Carmen Torres; Jesus Jimenez-Barbero; Alberto Avenoza; Jesus M. Peregrina;
展开▼
作者单位

Departamento de Quimica,Universidad de La Rioja,Centro de Investigation en Sintesis Quimica, UA-CSIC,Madre de Dios, 51, 26006 Logrono, Spain;

Departamento de Quimica,Universidad de La Rioja,Centro de Investigation en Sintesis Quimica, UA-CSIC,Madre de Dios, 51, 26006 Logrono, Spain;

Centro de Investigaciones Biologicas (CSIC), Madrid, Spain;

Departamento de Quimica,Universidad de La Rioja,Centro de Investigation en Sintesis Quimica, UA-CSIC,Madre de Dios, 51, 26006 Logrono, Spain;

Instituto de Quimica Organica General(CSIC),Madrid,spain;

Departamento de Quimica,Facultad de Farmacia,Universidad San Poblo CEU,Madrid,Spain;

Area de Microbiologia Molecular,Centro de Investigacion Biomedica de La Rioja(CIBIR),26006 Logrono,Spain;

Area de Microbiologia Molecular,Centro de Investigacion Biomedica de La Rioja(CIBIR),26006 Logrono,Spain,Area de Bioquimica y Biologia Molecular,Universidad de La Rioja,Area de Microbiologia Molecular,Centro de Investigacion Biomedica de La Rioja(CIBIR),26006 Logrono,Spain;

Centro de Investigaciones Biologicas (CSIC), Madrid, Spain;

Departamento de Quimica,Universidad de La Rioja,Centro de Investigation en Sintesis Quimica, UA-CSIC,Madre de Dios, 51, 26006 Logrono, Spain;

Departamento de Quimica,Universidad de La Rioja,Centro de Investigation en Sintesis Quimica, UA-CSIC,Madre de Dios, 51, 26006 Logrono, Spain;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Surface plasmon resonance and NMR analyses of anti Tn-antigen MLS128 monoclonal antibody binding to two or three consecutive Tn-antigen clusters [J] . Matsumoto-TakasakiA., HanashimaS., AokiA., The Journal of Biochemistry . 2012,第3期

机译：抗Tn抗原MLS128单克隆抗体与两个或三个连续的Tn抗原簇结合的表面等离子体共振和NMR分析
2. Surface plasmon resonance and NMR analyses of anti Tn-antigen MLS128 monoclonal antibody binding to two or three consecutive Tn-antigen clusters [J] . Ayano Matsumoto-Takasaki1 Shinya Hanashima2 Ami Aoki1 Noriyuki Yuasa1 Haruhiko Ogawa1 Reiko Sato3 Hiroko Kawakami3 Mamoru Mizuno3 Hiroshi Nakada4 Yoshiki Yamaguchi2 and Yoko Fujita-Yamaguchi1* Journal of Biochemistry . 2012,第3期

机译：抗Tn抗原MLS128单克隆抗体与两个或三个连续的Tn抗原簇结合的表面等离子体共振和NMR分析
3. Design of fully synthetic, self-adjuvanting vaccine incorporating the tumor-associated carbohydrate Tn antigen and lipoamino acid-based toll-like receptor 2 ligand [J] . Abdel-Aal A.-B.M., El-Naggar D., Zaman M., Journal of Medicinal Chemistry . 2012,第15期

机译：包含肿瘤相关碳水化合物Tn抗原和基于脂氨基酸的Toll样受体2配体的全合成自佐剂疫苗的设计
4. Multiple antigen glycopeptides (MAGs) with Tn tumor antigens and incorporated adjuvant:synthyesis and immunobiological activities [C] . Jan Jezek, Shree Kelkar, Pavel Veprek, European Peptide Symposium . 2002

机译：多种抗原糖肽（MAGS）与TN肿瘤抗原并掺入佐剂：合成和免疫生理活性
5. I. Immunological response from an entirely carbohydrate antigen: Design and synthesis of a cancer vaccine candidate based on Tn-PS A1 conjugate II. Microwave assisted one-pot two step synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones for cancer therapy. [D] . De Silva, Ravindra A. 2009

机译：I.完全由碳水化合物抗原引起的免疫反应：基于Tn-PS A1共轭物II的癌症疫苗候选物的设计和合成。微波辅助一锅两步合成1,2,4,5-四氢-1,4-苯并二氮杂-3-酮用于癌症治疗。
6. Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses [O] . Efthalia Zervoudi, Emmanuel Saridakis, James R. Birtley, 2013

机译：合理设计的靶向抗原修饰氨基肽酶的抑制剂可增强抗原呈递和细胞毒性T细胞反应
7. Globohexaosylceramide (globo-H); ganglioside GM2 (GM2); Thomsen-Friedenreich antigen (TF); Tn antigen (Tn); sialosyl-Tn antigen (sTn) [O] . 2009

机译：Globohexaosylcaramide（Globo-H）; Ganglioside gm2（GM2）; Thomsen-Friedenreich抗原（TF）; Tn抗原（TN）; Sialosyl-Tn抗原（STN）

Rational design of a Tn antigen mimicf

摘要

著录项

相似文献

相关主题

期刊订阅