A modular synthesis of dithiocarbamate pendant unnatural a-amino acids

摘要

Unnatural a-amino acids containing dithiocarbamate side chains were synthesized by a one-pot reaction of in situ generated dithiocarbamate anions with sulfamidates. A wide range of these anions participated in the highly regio- and stereo-selective ring opening of sulfamidates to produce the corresponding dithiocarbamate pendant a-amino acids in high yields.