Gold-catalyzed synthesis of substituted 2-aminofurans via formal [4 + 1]-cycloadditions on 3-en-1-ynamides

摘要

Gold-catalyzed formal [4 + 1]-cycloadditions between 3-en-1-ynamides 1 and 8-methylquinoline oxide are reported. The success of this reaction relies on a hypothetic oxa-Nazarov cyclization on gold-stabilized allylic cations. Preliminary results on a new 1,2-difunctionalization of 3-en-1-ynamide are also reported.