Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

摘要

Investigation of the hydrolysis of dinucleoside-arsenate-deoxy-guanylyl-3',5'-deoxyguanosine (dGAsdG~-) reveals that base-stacking in DNA increases the resistance of As-DNA towards hydrolysis. Base-stacking raises the activation energy of hydrolysis. Hydrolysis of As-DNA is found to be endothermic. The hydrolysis stability of As-DNA should be higher than that estimated based on arsenate diester models.