Iridium-catalyzed triple C(sp~3)-H borylations: construction of triborylated sp~3-carbon centers

摘要

An unprecedented catalytic C(sp~3)-H triborylation at a single carbon was developed with the assistance of a nitrogen directing group. Triborylated compounds possessing three boron atoms on the same carbon are extremely unique, exhibiting interesting reactivities toward many electrophiles. For the preparation of these fascinating molecules, traditional methods employed either triborylations of the corresponding trihalides or hydroborations of alkenes, borylalkynes, and borylalkenes with/without a transition metal catalyst.