A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

Javier Hernandez-Gil; Sacramento Ferrer; Elena Salvador; Javier Calvo; Enrique Garcia-Espana; Juan C. Mareque-Rivas

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A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

机译：一种双核配体，可通过一个或一个过渡金属离子来促进DNA切割

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摘要

The dinucleating ligand L(1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently deaves DNA when M:L is 1:1 (M = Co(II) or Fe(III)) at pH 5.5-7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.

机译：当M：L为1：1时（M = Co（II）或Fe（III））在pH 5.5-7.0的情况下，与在中性pH下与Zn（II），Cu（II）或Ni（II）结合时相比，游离L在酸性pH下的活性更高。

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来源
《Chemical Communications》 |2013年第35期|3655-3657|共3页
作者
Javier Hernandez-Gil; Sacramento Ferrer; Elena Salvador; Javier Calvo; Enrique Garcia-Espana; Juan C. Mareque-Rivas;
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Departament de Quimica Inorganica, Facultat de Farmacia, Unnersitat de Valencia,46100-Burjassot, Valencia, Spain;

Departament de Quimica Inorganica, Facultat de Farmacia, Unnersitat de Valencia,46100-Burjassot, Valencia, Spain;

Departamento de Quimica, Inorganica, Unwersidad de Valencia, Institvto de Ciencia Molecular, Edificio de Institutes de Paterna Apdo 22085, 46071, Valencia, Spain;

Cooperative Centre for Research in Biomaterials (CiC biomaGUNE),20009 San Sebastian, Spain;

Departamento de Quimica, Inorganica, Unwersidad de Valencia, Institvto de Ciencia Molecular, Edificio de Institutes de Paterna Apdo 22085, 46071, Valencia, Spain;

Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain;

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A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

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