Pd(Ⅱ)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation

摘要

A palladium-catalyzed decarboxylative acylation of phenylacet-amides with α-oxocarboxylik acids via C-H bond activation is described. This protocol provides efficient access to a range of ort/io-acyl phenylacetamides, which can be easily converted to 3-isochromanone derivatives. The development of new carbon-carbon bond-forming reactions continues to be an essential goal in organic chemistry. Traditional metal-catalyzed cross-coupling reactions between aryl metal reagents and aryl halides are well-established methods for the construction of C-C bonds and synthesis of complex molecules.