In situ amplified electronic signal for determination of low-abundance proteins coupling with nanocatalyst-based redox cycling

摘要

Platinum-cerium oxide hybrid nanocatalysts (CeO_2-Pt) were for the first time designed as bionanolabels for highly efficient electrochemical immunosensing of low-abundance proteins coupling nanocatalyst-based redox cycling with in situ signal amplification strategy. Detectable signal amplification is one of the most important strategies in lowering the detection limit and increasing the sensitivity of electrochemical immunoassays. Redox cycling is a process that can repetitively generate or consume signalling species (molecules or electrons) in the presence of reversible redox species.