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首页> 外文期刊>Chemical Communications >A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation
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A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

机译：γ-谷氨酰转肽酶触发的一类新的NO供体前体药物，可能具有肾选择性血管舒张作用

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摘要

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
机译：该通报描述了一种新型的N-羟基胍（NHG）前药的合成，该前药可通过γ-谷氨酰转肽酶（γ-GT）的作用触发释放一氧化氮（NO），并可能用于治疗急性肾损伤/失败（ARI / ARF）。

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  • 来源
    《Chemical Communications》 |2013年第14期|1389-1391|共3页
  • 作者

    Qingzhi Zhang; Agnieszka Kulczynska; David J. Webb; Ian L. Megson; Nigel P. Botting;

  • 作者单位

    University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife KY16 9ST, UK;

    University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife KY16 9ST, UK;

    Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK;

    Free Radical Research Facility, Department of Diabetes and Cardiovascular Science, The University of The Highlands & Islands, Centre for Health Science, Old Perth Road, Inverness, IV2 3JH, UK;

    University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife KY16 9ST, UK;

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  • 入库时间 2022-08-17 13:17:57

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