首页>
外国专利>
Gamma-glutamyl transpeptidase-specific antibody, prodrugs for the treatment of gamma-glutamyl transpeptidase-expressing tumors, and methods of administration thereof
Gamma-glutamyl transpeptidase-specific antibody, prodrugs for the treatment of gamma-glutamyl transpeptidase-expressing tumors, and methods of administration thereof
展开▼
机译:γ-谷氨酰转肽酶特异性抗体,用于治疗表达γ-谷氨酰转肽酶的肿瘤的前药及其给药方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
An antibody is provided which binds to active GGT, and can identify tissues which express GGT on their surface. Many solid tumors express GGT on their surface. Individuals identified with such tumors may be treated with inactivated prodrugs of chemotherapeutic agents at local dosage levels substantially above the maximum dosage levels currently permitted due to side effect limitations. The prodrugs are comprised of chemotherapeutic agents rendered inactive by the attachment of a gamma- glutamyl group thereto. The gamma-glutamyl group is cleaved by GGT on the surface of solid tumor cells expressing GGT, and thus active only locally against the tumor. Side effects are suppressed. The antibody is used to identify solid tumors that are candidates for this treatment, as well as to identify tissues which express GGT and which must therefore be the basis of selection criteria of various available chemotherapeutic agents.
展开▼