Discovery of new G-quadruplex binding chemotypes

Stephan A. Ohnmacht; Ehsan Varavipour; Rupesh Nanjunda; Ingrida Pazitna; Gloria Di Vita; Mekala Gunaratnam; Arvind Kumar; Mohamed A. Ismail; David W. Boykin; W. David Wilson; Stephen Neidle

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Discovery of new G-quadruplex binding chemotypes

机译：发现新的G-四链体结合化学型

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We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent In vitro anti-proliferative activity.

机译：我们在这里报告的发现和初步评估新型非大环低分子量四链体稳定化学型。基于呋喃核的先导化合物显示出高的G-四链体稳定性和选择性以及有效的体外抗增殖活性。

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《Chemical Communications》 |2014年第8期|960-963|共4页
作者
Stephan A. Ohnmacht; Ehsan Varavipour; Rupesh Nanjunda; Ingrida Pazitna; Gloria Di Vita; Mekala Gunaratnam; Arvind Kumar; Mohamed A. Ismail; David W. Boykin; W. David Wilson; Stephen Neidle;
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School of Pharmacy, University College London, London WC1N 1AX, UK;

School of Pharmacy, University College London, London WC1N 1AX, UK;

Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30303-3083, USA;

School of Pharmacy, University College London, London WC1N 1AX, UK;

School of Pharmacy, University College London, London WC1N 1AX, UK;

School of Pharmacy, University College London, London WC1N 1AX, UK;

Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30303-3083, USA;

Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30303-3083, USA;

Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30303-3083, USA;

Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30303-3083, USA;

School of Pharmacy, University College London, London WC1N 1AX, UK;

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入库时间 2022-08-17 13:14:55

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专利

1. Investigation of Na+ and K+ Competitively Binding with a G-Quadruplex and Discovery of a Stable K+-Na+-Quadruplex [J] . Ma Ge, Yu Ze, Zhou Wei, The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2019,第26期

机译：与稳定K + -NA + -Quadruplex的G-Quadreplex和发现竞争结合Na +和K +竞争结合
2. Insights into the Competition between K+ and Pb2+ Binding to a G-Quadruplex and Discovery of a Novel K+-Pb2+-Quadruplex Intermediate [J] . Yu Ze, Zhou Wei, Ma Ge, The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2018,第40期

机译：在K +和PB2 +与G-Quadruple和Discovery的竞争中欣赏到G-Quadruple和Discovey的k + -pb2 + -quadruplex中间体的竞争
3. Discovery of a Drug-Like G-Quadruplex Binding Ligand by High-Throughput Docking [J] . Dik-Lung Ma, Tat-Shing Lai, Fung-Yi Chan ChemMedChem . 2008,第6期

机译：通过高通量对接发现类似药物的G-四链体结合配体
4. Discovery of G-quadruplex DNA binding proteins using MALDI-MS and LC/MS [C] . Yuexi Wang, Huiping Zhang, Linda B. McGown American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：使用MALDI-MS和LC / MS发现G-Quadrepled DNA结合蛋白
5. Interactions of DNA binding proteins with G-Quadruplex structures at the single molecule level [D] . Ray, Sujay 2014

机译：DNA结合蛋白与G-四链体结构在单分子水平上的相互作用
6. Discovery of new G-quadruplex binding chemotypes [O] . Stephan A. Ohnmacht, Ehsan Varavipour, Rupesh Nanjunda, -1

机译：发现新的G-四链体结合化学型
7. Discovery of new G-quadruplex binding\ud chemotypes [O] . Ohnmacht, S, Varavipour, E, Nanjunda, R, 2014

机译：发现新的G-四链体结合物\ ud 化学型

Discovery of new G-quadruplex binding chemotypes

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