A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction

摘要

Combined regioselective acylation/Michael addition reaction catalyzed by alkaline protease from Bacillus subtilis in anhydrous pyridine for synthesis of N-substituted imidazole derivatives containing a glucose branch via a novel single-enzyme, two-step, one-pot procedure is reported.