Tuneable asymmetric copper-catalysed allylic animation and oxidation reactions

摘要

Asymmetric allylic amination or oxidation can be achieved by reaction of an alkene with a peroxycarbamate catalysed by a chiral copper bis-oxazoline complex,and the reaction can be tuned to give either the amination or oxidation product by reagent choice.The discovery of new catalytic asymmetric allylic oxidation reactions has been the objective of much research over the past decade.In 1995,the groups of Pfaltz and Andrus reported the enantioselective allylic oxidation of alkenes using a copper bis-oxazoline complex as the catalyst and a perester as the stoichiometric oxidant.