The depth of molecular recognition:voltage-sensitive blockage of synthetic multifunctional pores with refined architecture

摘要

Voltage-sensitive blockage by ADP,ATP and phytate (IP_6) demonstrates that active-site contraction toward the middle of newly synthesized rigid-rod beta-barrels provides a general strategy to rationally create and modulate the voltage sensitivity (and to increase the efficiency) of molecular recognition by synthetic multifunctional pores.