Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

Khan A; Silversides JD; Madden L; Greenman J; Archibald SJ

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Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

机译：荧光CXCR4趋化因子受体拮抗剂：金属激活的结合

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The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

机译：新型若丹明-金刚花环偶联物的铜（II）配合物与CXCR4趋化因子受体结合并有效对抗抗CXCR4单克隆抗体。铜大环单元在固态下采用反式II结构。

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来源
《Chemical Communications》 |2007年第4期|p. 416-418|共3页
作者
Khan A; Silversides JD; Madden L; Greenman J; Archibald SJ;
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作者单位

Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England;

Univ Hull, Inst Clin Biosci, Kingston Upon Hull HU6 7RX, N Humberside, England;

Univ Hull, Med Res Lab, Kingston Upon Hull HU6 7RX, N Humberside, England;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
COPPER(II) COMPLEXES; AMD3100; RECOGNITION; MACROCYCLE; CYCLAM; POTENT; ENTRY;

机译：铜（II）配合物;AMD3100;识别;大分子;循环;势力;进入;
入库时间 2022-08-17 13:28:13

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专利

1. Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding [J] . Abid Khan, Jon D. Silversides, Leigh Madden, Chemical Communications . 2007,第4期

机译：荧光CXCR4趋化因子受体拮抗剂：金属激活的结合
2. Binding Optimization Through Coordination Chemistry: Cxcr4 Chemokine Receptor Antagonists From Ultrarigid Metal Complexes [J] . Abid Khan, Gary Nicholson, John Greenman, Journal of the American Chemical Society . 2009,第10期

机译：通过配位化学的结合优化：超刚性金属络合物的Cxcr4趋化因子受体拮抗剂。
3. Fluorescent imaging of high-grade bladder cancer using a specific antagonist for chemokine receptor CXCR4. [J] . Nishizawa K, Nishiyama H, Oishi S, International Journal of Cancer =: Journal International du Cancer . 2010,第5期

机译：使用趋化因子受体CXCR4的特异性拮抗剂对高级别膀胱癌进行荧光成像。
4. Development of Chemokine Receptor CXCR4 Antagonists Using Bio-mimetic Strategy [C] . Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi American Peptide Symposium . 2009

机译：使用生物模拟策略的趋化因子受体CXCR4拮抗剂的发展
5. Prediction of structure and antagonist binding site in human and rodent chemokine receptor 1. [D] . Sharma, Shantanu. 2005

机译：人类和啮齿动物趋化因子受体1的结构和拮抗剂结合位点的预测
6. Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultra rigid metal complexes [O] . Abid Khan, Gary Nicholson, John Greenman, -1

机译：从超刚性金属配合物CXCR4趋化因子受体拮抗剂：通过配位化学结合优化
7. Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding† †Electronic supplementary information (ESI) available: Experimental procedures (microbiology and chemical synthesis), fluorescence emission spectra and X-ray crystallographic data. See DOI: 10.1039/b614557d Click here for additional data file. Click here for additional data file. [O] . Khan, Abid, Silversides, Jon D., Madden, Leigh, 2007

机译：荧光CXCR4趋化因子受体拮抗剂：金属激活结合† †可用的电子补充信息（ESI）：实验程序（微生物学和化学合成），荧光发射光谱和X射线晶体学数据。参见DOI：10.1039 / b614557d 单击此处获取其他数据文件。单击此处获取其他数据文件。

Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

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