Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

Ian Paterson; Nicola M. Gardner

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Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

机译：大环二茂肽/双顺他汀杂种的设计，合成及生物学评价

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A 22-membered macrocyclic discodermolide/dictyostatin hybrid has been designed and synthesised; biological evaluation against a range of human cancer cell lines revealed significant levels of growth inhibition.

机译：已经设计并合成了一个22元大环二茂铁/柔他汀混合剂。对一系列人类癌细胞系的生物学评估显示出显着水平的生长抑制。

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来源
《Chemical Communications》 |2007年第1期|p.49-51|共3页
作者
Ian Paterson; Nicola M. Gardner;
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University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW;

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正文语种 eng
中图分类化学;
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1. Total Synthesis and Biological Evaluation of a Series of Macrocyclic Hybrids and Analogues of the Antimitotic Natural Products Dictyostatin, Discodermolide, and Taxol [J] . Ian Paterson, Guy J. Naylor, Nicola M. Gardner, Chemistry, an Asian journal . 2011,第2期

机译：一系列大环杂种的全合成和生物学评价以及抗有丝分裂天然产物杀螨抑素，二甲蝶呤和紫杉醇的类似物。
2. Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation [J] . Youseung Shin, Nakyen Choy, Raghavan Balachandran, Organic letters . 2002,第25期

机译：Discodermolide / Dictyostatin杂种：合成和生物学评价。
3. Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin [J] . Ian Paterson, Guy J. Naylor, Takeshi Fujita, Chemical Communications . 2010,第2期

机译：全合成的微管稳定抗癌药紫杉醇，双降糖醇和双歧抑素的设计杂交体文库
4. Design,synthesis and biological evaluation of α-helix mimeticscomposed of skeletally diverse macrocyclic mid-sized scaffolds [C] . Takahiro Shimizu, Huber Vincent, Atsushi Yoshimori 日本化学会春季年会 . 2020

机译：α-Helix模拟性骨骼多种宏茂的中型支架的设计，合成和生物学评价
5. Design and synthesis of molecular probes to modulate cell membrane permeation: I. Design, synthesis, and biological evaluation of novel chicoric acid analogues as inhibitors of HIV-1 integrase. II. Design, synthesis, and biological evaluation of novel estradiol analogues targeting the membrane estrogen receptor. [D] . Charvat, Trevor Thomas. 2004

机译：设计和合成的分子探针，可调节细胞膜的渗透性：I.设计，合成和生物评价作为抗HIV-1整合酶抑制剂的新型菊苣酸类似物。二。针对膜雌激素受体的新型雌二醇类似物的设计，合成和生物学评估。
6. Total Synthesis and Biological Evaluation of a Series of Macrocyclic Hybrids and Analogues of the Antimitotic Natural Products Dictyostatin Discodermolide and Taxol [O] . Ian Paterson, Guy J. Naylor, Nicola M. Gardner, -1

机译：一系列宏环杂交种的总合成和生物学评价和抗粘结泡天然产物DictyostatinDiscodermolide和紫杉醇的类似物
7. Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation [O] . Youseung Shin, Nakyen Choy, Tiffany R. Turner, 2003

机译：Discodermolide / Dictyostatin杂种：合成和生物学评估

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

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