An Efficient Process for the Cyclization of N-β-hydroxyethyl-N-methyl-1,3-propanediamine to N-methylhomopiperazine Over Cu₂₀Cr₁₀Mg₁₀/γ-Al₂O₃

摘要

Abstract Continuous synthesis of N-methylhomopiperazine over Cu–Cr–Mg/γ-Al₂O₃ has been developed. The doped Cr improves the dispersion of the Cu0 particles and inhibits the generation of CuAl₂O₄ so that the Cu0 particles are retained as the active sites. Doped Mg neutralizes the strong acid sites in Cu₂₀Cr₁₀Mg₁₀/γ-Al₂O₃, and led to a decrease in coking side reactions. The reaction parameters were optimized and N-methylhomopiperazine was obtained in a yield of 66%.