An Efficient Process for the Cyclization of N-β-hydroxyethyl-N-methyl-1,3-propanediamine to N-methylhomopiperazine Over Cu_(20)Cr_(10)Mg_(10)/γ-Al2O3

摘要

Continuous synthesis of N-methylhomopiper-azine over Cu-Cr-Mg/γ-Al2O3 has been developed. The doped Cr improves the dispersion of the Cu° particles and inhibits the generation of CuAl2O4 so that the Cu° particles are retained as the active sites. Doped Mg neutralizes the strong acid sites in Cu_(20)Cr_(10)Mg_(10)/γ-Al2O3, and led to a decrease in coking side reactions. The reaction parameters were optimized and N-methylhomopiperazine was obtained in a yield of 66%.