Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy

Jorge Espinoza-Derout Michael Wagner Katayoun Shahmiri Eduardo Mascareno Brahim Chaqour and M.A.Q. Siddiqui

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Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy

机译：心脏谱系蛋白1（CLP-1）在心脏肥大中转录延伸因子P-TEFb复合体形成中的关键作用

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Objective Our aim was to determine if the expression pattern of CLP-1 in developing heart is consistent with its role in controlling RNA transcript elongation by transcriptional elongation factor b (P-TEFb) and if the inhibitory control exerted over P-TEFb by CLP-1 is released under hypertrophic conditions.

机译：目的我们的目的是确定CLP-1在发育中的心脏中的表达模式是否与其通过转录延伸因子b（P-TEFb）控制RNA转录延伸的作用相一致，以及CLP-对C--1发挥抑制作用。 1在肥大条件下释放。

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《Cardiovascular Research》 |2007年第1期|129-138|共10页
作者
Jorge Espinoza-Derout Michael Wagner Katayoun Shahmiri Eduardo Mascareno Brahim Chaqour and M.A.Q. Siddiqui;
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Center for Cardiovascular and Muscle Research and Department of Anatomy and Cell Biology State University of New York Downstate Medical Center Brooklyn New York 11203 United States;

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专利

1. Cardiac Lineage Protein-1 (CLP-1) Regulates Cardiac Remodeling via Transcriptional Modulation of Diverse Hypertrophic and Fibrotic Responses and Angiotensin II-transforming Growth Factor β (TGF-β1) Signaling Axis [J] . Eduardo Mascareno, Josephine Galatioto, Inna Rozenberg, The Journal of biological chemistry . 2012,第16期

机译：心脏谱系蛋白-1（CLP-1）通过转录调节多样化肥厚和纤维化反应和血管紧张素II转化生长因子β（TGF-β1）信号轴的转录调节，调节心脏重塑
2. Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1. [J] . Espinoza Derout J, Wagner M, Salciccioli L Circulation research: a journal of the American Heart Association . 2009,第12期

机译：代偿性心肌肥大中的正转录延伸因子b活性受心脏谱系蛋白1调节。
3. Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene [J] . Sonja Gawlas, Yassemi Capetanaki, Christiane Fuchs, Biology Open . 2016,第2期

机译：Desmin进入心脏干细胞核并通过参与与nkx2.5基因相互作用的转录因子复合物调节Nkx2.5表达Desmin进入心脏干细胞的核并通过参与相互作用的转录因子复合物调节Nkx2.5表达与nkx2.5基因结合的Desmin通过参与与nkx2.5基因相互作用的转录因子复合物进入心脏干细胞核并调节Nkx2.5表达
4. CREB-binding Protein (CBP) p300 Enhanced the Expression of Cardiac Hypertrophy-Specific Genes Activated by Myocardin-Related Transcription Factor-A (MRTF-A) [C] . Li Mingzhe, Wang Zhenyu, Xie Zhongyi, Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：CREB结合蛋白（CBP）p300增强心肌相关转录因子-A（MRTF-A）激活的心肌肥大基因的表达。
5. Role of transcription factors in the pathomechanism of cardiac hypertrophy. [D] . Sarman, Balazs. 2007

机译：转录因子在心脏肥大的发病机制中的作用。
6. Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy [O] . Jorge Espinoza-Derout, Michael Wagner, Katayoun Shahmiri, -1

机译：心脏谱系蛋白1（CLP-1）在心脏肥大中转录延伸因子P-TEFb复合体形成中的关键作用
7. Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy [O] . J ESPINOZADEROUT, M WAGNER, K SHAHMIRI, 2007

机译：心脏谱系蛋白-1（CLP-1）在心肌肥大转录伸长因子P-TEFB复合物中的枢转作用

Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy

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