Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes

摘要

Aims Hydrogen sulphide (H₂S) is an endogenously generated gaseous transmitter that has recently been suggested to regulate cardiovascular functions. To date, there is no direct evidence for a potential role of H₂S in regulating calcium channels in the heart. The present study aims to examine the hypothesis that H₂S is a novel inhibitor of the L-type calcium channel current (I_Ca,L).