Role of HIF-1α in proton-mediated CXCR4 down-regulation in endothelial cells

Roberta Melchionna; Marta Romani; Valeria Ambrosino; Daniela DArcangelo; Chiara Cencioni; Daniele Porcelli; Gabriele Toietta; Silvia Truffa; Carlo Gaetano; Antonella Mangoni; Ombretta Pozzoli; Claudia Cappuzzello; Maurizio C. Capogrossi; Monica Napolitano

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Role of HIF-1α in proton-mediated CXCR4 down-regulation in endothelial cells

机译：HIF-1α在质子介导的CXCR4内皮细胞下调中的作用

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Aims Acidification is associated with a variety of pathological and physiological conditions. In the present study, we aimed at investigating whether acidic pH may regulate endothelial cell (EC) functions via the chemokine receptor CXCR4, a key modulator of EC biological activities.

机译：目的酸化与多种病理和生理状况有关。在本研究中，我们旨在研究酸性pH是否可以通过趋化因子受体CXCR4（EC生物活性的关键调节剂）调节内皮细胞（EC）的功能。

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《Cardiovascular Research》 |2010年第2期|p.293-301|共9页
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Roberta Melchionna; Marta Romani; Valeria Ambrosino; Daniela DArcangelo; Chiara Cencioni; Daniele Porcelli; Gabriele Toietta; Silvia Truffa; Carlo Gaetano; Antonella Mangoni; Ombretta Pozzoli; Claudia Cappuzzello; Maurizio C. Capogrossi; Monica Napolitano;
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1. Role of HIF-1alpha in proton-mediated CXCR4 down-regulation in endothelial cells. [J] . Melchionna R, Romani M, Ambrosino V, Cardiovascular Research . 2010,第2期

机译：HIF-1alpha在质子介导的CXCR4内皮细胞下调中的作用。
2. CXCR4 down-regulation by small interfering RNA inhibits invasion and tubule formation of human retinal microvascular endothelial cells [J] . Yu KM, Zhuang J, Kaminski JM, Biochemical and Biophysical Research Communications . 2007,第4期

机译：CXCR4下调的小分子干扰RNA抑制人视网膜微血管内皮细胞的侵袭和小管形成
3. The number of circulating endothelial cells is not increased in systemic sclerosis and related disorders: assessment of the pathogenetic role played by cxcr4(pos) progenitor cells coexpressing monocytic and endothelial markers [J] . Carnpioni D, Lo Monaco A, Lanza F, Cytometry, Part A: the journal of the International Society for Analytical Cytology . 2008,第1期

机译：在系统性硬化症和相关疾病中循环内皮细胞的数量没有增加：共同表达单核细胞和内皮标记物的cxcr4（pos）祖细胞的致病作用评估
4. Pravastatin Attenuates Ceramide-Induced Cytotoxicity in Mouse Cerebral Endothelial Cells with HIF-1 Activation and VEGF Upregulation [C] . SHANG-DER CHEN, CHAUR-JONG HU, DING-I YANG, Asian Society for Mitochondrial Research and Medicine . 2005

机译：普伐他汀在小鼠脑内皮细胞中衰减宫胺诱导的细胞毒性，HIF-1活化和VEGF上调
5. Regulation of the chemokine receptor CXCR4 on colorectal carcinoma cells by the tumor microenvironment: The role of adenosine and prostaglandins. [D] . Richard, Cynthia Lee. 2006

机译：肿瘤微环境对大肠癌细胞上趋化因子受体CXCR4的调节：腺苷和前列腺素的作用。
6. High-density lipoprotein remodelled in hypercholesterolaemic blood induce epigenetically driven down-regulation of endothelial HIF-1α expression in a preclinical animal model [O] . Soumaya Ben-Aicha, Rafael Escate, Laura Casaní, -1

机译：在高胆固醇血症的血液中重塑的高密度脂蛋白诱导表观遗传驱动的临床前动物模型中内皮HIF-1α表达的下调
7. Role of HIF-1α in proton-mediated CXCR4 down-regulation in endothelial cells [O] . Roberta Melchionna, Marta Romani, Valeria Ambrosino, 2009

机译：HIF-1α在质子介导的内皮细胞中介导的CXCR4下调的作用

Role of HIF-1α in proton-mediated CXCR4 down-regulation in endothelial cells

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