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Novel Concepts in the Genesis of Hypertension: Role of LOX-1

机译:高血压成因中的新概念:LOX-1的作用

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摘要

Hypertension is a common disease and a potent risk factor for cardiovascular disease. Tremendous strides have been made in understanding its genesis in the last 2 decades. Hypertension is often clustered with other cardiovascular risk factors, such as dyslipidemia and diabetes. The state of hypertension is often associated with increased vascular oxidative stress. Oxidative stress promotes proliferation and hypertrophy of vascular smooth muscle cell and collagen deposition, leading to thickening of the vascular media and narrowing of the vascular lumen. Oxidative stress also injures endothelium, impairs endothelium-dependent vascular relaxation and increases vascular contractile activity. Further, oxidative stress also oxidizes LDL-cholesterol. It has been shown that oxidized low-density lipoprotein (ox-LDL) activates renin-angiotensin system (RAS) and angiotensin II via its type 1 receptor activates ox-LDL receptor LOX-1. This mutually facilitative cross-talk between ox-LDL and RAS may be an important component in the development of hypertension. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a receptor for ox-LDL. This review summarizes the role of LOX-1 in the pathogenesis of hypertension.
机译:高血压是一种常见疾病,也是心血管疾病的潜在危险因素。在过去20年中,在了解其起源方面取得了巨大进步。高血压通常与其他心血管危险因素如血脂异常和糖尿病有关。高血压状态通常与血管氧化应激增加有关。氧化应激促进血管平滑肌细胞的增生和肥大以及胶原蛋白的沉积,导致血管介质增厚和血管腔狭窄。氧化应激还会损伤内皮,损害内皮依赖性血管舒张并增加血管收缩活性。此外,氧化应激还氧化LDL-胆固醇。已经显示,氧化的低密度脂蛋白(ox-LDL)激活肾素-血管紧张素系统(RAS),而血管紧张素II通过其1型受体激活ox-LDL受体LOX-1。 ox-LDL和RAS之间的这种相互促进的相互作用可能是高血压发展的重要组成部分。凝集素样氧化的低密度脂蛋白受体1(LOX-1)是ox-LDL的受体。这篇综述总结了LOX-1在高血压发病机制中的作用。

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