A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors

Matthew G. Fury; Allan Lipton; Katherine M. Smith; Corinne B. Winston; David G. Pfister

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A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors

机译：表皮生长因子受体指导的双特异性抗体MDX-447不含或含重组人粒细胞集落刺激因子的I期试验在晚期实体瘤患者中的应用

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MDX-447 is a bispecific antibody directed against the epidermal growth factor receptor (EGFR) and the high affinity Fc receptor (FcγRI). Preclinical data suggest that co-administration of granulocyte-colony stimulating factor (G-CSF) may enhance the tumor cytotoxicity of bispecific antibodies.

机译：MDX-447是针对表皮生长因子受体（EGFR）和高亲和力Fc受体（FcγRI）的双特异性抗体。临床前数据表明，粒细胞集落刺激因子（G-CSF）的共同给药可能会增强双特异性抗体的肿瘤细胞毒性。

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《Cancer Immunology, Immunotherapy》 |2008年第2期|155-163|共9页
作者
Matthew G. Fury; Allan Lipton; Katherine M. Smith; Corinne B. Winston; David G. Pfister;
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作者单位

Division of Solid Tumor Oncology Head and Neck Medical Oncology Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York NY 10021 USA;

Department of Medicine Milton S. Hershey Medical Center Hershey PA 17033 USA;

Department of Clinical Laboratories Memorial Sloan-Kettering Cancer Center New York NY 10021 USA;

Department of Radiology Memorial Sloan-Kettering Cancer Center New York NY 10021 USA;

Division of Solid Tumor Oncology Head and Neck Medical Oncology Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York NY 10021 USA;

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1. Phase I Study of the Humanized Antiepidermal Growth Factor Receptor Monoclonal Antibody EMD72000 in Patients With Advanced Solid Tumors That Express the Epidermal Growth Factor Receptor. [J] . Vanhoefer U, Rojo F, Schleucher N, Journal of Clinical Oncology . 2004,第1期

机译：人源化抗表皮生长因子受体单克隆抗体EMD72000在患有表皮生长因子受体的晚期实体瘤患者中的研究。
2. A First‐in‐Human Phase I Study of GC1118, a Novel Anti‐Epidermal Growth Factor Receptor Antibody, in Patients with Advanced Solid Tumors [J] . Oh Do‐Youn, Lee Keun‐Wook, Han Sae‐Won, The oncologist . 2019,第8期

机译：先进的实体肿瘤患者，我对新型抗表皮生长因子受体抗体研究GC11的第一类阶段研究
3. A First-in-Human Phase I Study of GC1118, a Novel Anti-Epidermal Growth Factor Receptor Antibody, in Patients with Advanced Solid Tumors [J] . Do-Youn Oh, Woo Ho Kim, Yung-Jue Bang, The oncologist . 2019,第8期

机译：先进的实体肿瘤患者，我对新型抗表皮生长因子受体抗体研究GC11的第一类阶段研究
4. HER1 THERAPEUTIC CANCER VACCINE: AN ACTIVE IMMUNOTHERAPY TREATMENT FOR PATIENTS WITH TUMORS EXPRESSING THE RECEPTOR OF EPIDERMAL GROWTH FACTOR (EGF-R) [C] . Eduardo Suarez, Belinda Sanchez, Zaima Mazorra, Conference on vaccine technology VI . 2018

机译：HER1癌症治疗疫苗：一种针对表皮生长因子（EGF-R）受体的肿瘤的主动免疫疗法
5. Cloning and expression of a biosimilar chimeric monoclonal antibody directed against the human epidermal growth factor receptor and its production in CHO cells for treatment of colo-rectal cancer. [D] . Motiwala, Hatim Maqbulhusen. 2012

机译：针对人表皮生长因子受体的生物仿制药嵌合单克隆抗体的克隆和表达及其在CHO细胞中的产生，用于治疗结肠直肠癌。
6. A First‐in‐Human Phase I Study of GC1118 a Novel Anti‐Epidermal Growth Factor Receptor Antibody in Patients with Advanced Solid Tumors [O] . Do‐Youn Oh, Keun‐Wook Lee, Sae‐Won Han, 2019

机译：新型抗表皮生长因子受体抗体GC1118在晚期实体瘤患者中的首次人体I期研究
7. A Fully Human Recombinant IgG-like Bispecific Antibody to Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor for Enhanced Antitumor Activity [O] . Dan Lu, Haifan Zhang, Henry Koo, 2005

机译：表皮生长因子受体和胰岛素样生长因子受体的完全人重组IgG样的双特异性抗体，用于增强抗肿瘤活性
8. Interdependence of the Radioprotective Effects of Human Recombinant Interleukin 1alpha, Tumor Necrosis Factor alpha, Granulocyte Colony-Stimulating Factor, and Murine Recombinant Granulocyte-Macrophage Colony-Stimulating Factor [R] . Neta, R., Oppenheim, J. J., Douches, S. D. 1988

机译：人重组白细胞介素1α，肿瘤坏死因子α，粒细胞集落刺激因子和小鼠重组粒细胞 - 巨噬细胞集落刺激因子的辐射保护作用的相互依赖性

A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors

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