A phase I study of gemcitabine plus palliative radiation therapy for advanced lung cancer

Brian Choi; H. Ian Robins; Joan Schiller; Minesh Mehta

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A phase I study of gemcitabine plus palliative radiation therapy for advanced lung cancer

机译：吉西他滨联合姑息性放射疗法治疗晚期肺癌的I期研究

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摘要

To determine the maximum-tolerated dose (MTD) and antitumor activity of twice-weekly gemcitabine when combined with palliative-dose thoracic radiation therapy (RT) in patients with recurrent or progressive lung cancer.

机译：为了确定复发或进行性肺癌患者每周两次吉西他滨联合姑息剂量胸腔放疗（RT）的最大耐受剂量（MTD）和抗肿瘤活性。

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《Cancer Chemotherapy and Pharmacology 》 |2008年第1期| 175-179| 共5页
作者
Brian Choi; H. Ian Robins; Joan Schiller; Minesh Mehta;
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作者单位

Department of Medicine University of Wisconsin Madison WI 53792 USA;

Department of Medicine University of Wisconsin Madison WI 53792 USA;

Department of Internal Medicine UT Southwestern Dallas TX 75390 USA;

Department of Human Oncology University of Wisconsin K4/3 600 Highland Ave. Madison WI 53792 USA;

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原文格式 PDF
正文语种 eng
中图分类
关键词
Lung cancer; Gemcitabine; Radiosensitizers; Phase I; Palliative radiation;

机译：肺癌;吉西他滨;放射增敏剂;第一阶段;姑息性放射治疗;

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专利

1. A phase I study of gemcitabine plus palliative radiation therapy for advanced lung cancer [J] . Brian Choi ? H. Ian Robins ? Joan Schiller ? Minesh Mehta Cancer chemotherapy and pharmacology. . 2009 ,第1期

机译：吉西他滨联合姑息性放射疗法治疗晚期肺癌的I期研究
2. A phase I study of moderate-dose radiation therapy and weekly gemcitabine in patients with locally advanced non-small cell lung cancer not suitable for radical chemoradiation therapy. [J] . Burmeister BH, Fielding DI, Ramsay JR, Clinical oncology . 2005 ,第5期

机译：对于不适合进行根治性化学放射治疗的局部晚期非小细胞肺癌患者，中等剂量放射治疗和每周吉西他滨的I期研究。
3. A phase II single-arm study of induction chemotherapy with cisplatin and gemcitabine followed by concurrent cisplatin and gemcitabine with thoracic radiation for unresectable locally advanced non-small cell lung cancer. [J] . Peter Driesen, Marc Lambrechts, Kees Kraaij, Therapeutic advances in medical oncology. . 2013 ,第3期

机译：不可逆转局部晚期非小细胞肺癌的顺铂和吉西他滨诱导化疗联合顺铂和吉西他滨联合胸腔放疗的II期单臂研究。
4. CHANGES IN LUNG PERFUSION DISTRIBUTION DUE TO RADIATION IN LUNG CANCER PATIENTS TREATED WITH 3D CONFORMAL RADIATION THERAPY AND STEREOTACTIC BODY RADIATION THERAPY [C] . Lingshu Yin, Mitchell Liu, Jonn Wu, World Congress on Medical Physics and Biomedical Engineering . 2013

机译：3D保形放射治疗和定性体放射治疗对肺癌患者放射致肺灌注分布的变化
5. Assessing the effectiveness of palliative chemotherapy for non-small cell lung cancer: A phase IV study of patients treated at Ontario's cancer centres [D] . Harrison, Lyndsay Dawn. 2012

机译：评估姑息化疗对非小细胞肺癌的有效性：在安大略省癌症中心接受治疗的患者的IV期研究
6. A phase II single-arm study of induction chemotherapy with cisplatin and gemcitabine followed by concurrent cisplatin and gemcitabine with thoracic radiation for unresectable locally advanced non-small cell lung cancer [O] . Peter Driesen, Marc Lambrechts, Kees Kraaij, 2013

机译：顺铂联合吉西他滨诱导化疗联合胸腔放化疗联合顺铂和吉西他滨治疗不可切除的局部晚期非小细胞肺癌的II期单臂研究
7. A randomized phase II trial assessing in advanced non-small cell lung cancer patients with stable disease after two courses of cisplatin-gemcitabine an early modification of chemotherapy doublet with paclitaxel-gemcitabine versus continuation of cisplatin-gemcitabine chemotherapy (GFPC 03-01 Study). [O] . Vergnenègre Alain, Tillon Julie, Corre Romain, 2009

机译：一项II期随机临床试验，评估了在接受两个疗程的顺铂-吉西他滨，紫杉醇-吉西他滨对化疗双重治疗的早期改良与继续进行顺铂-吉西他滨化疗之后的稳定疾病的晚期非小细胞肺癌患者（GFPC 03-01研究）。

A phase I study of gemcitabine plus palliative radiation therapy for advanced lung cancer

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