Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer

Geoffrey Y. Ku; David H. Ilson; Lawrence H. Schwartz; Marinela Capanu; Eileen O’Reilly; Manish A. Shah; David P. Kelsen; Gary K. Schwartz

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Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer

机译：晚期食管癌患者序贯紫杉醇和bryostatin-1的1小时输注的II期试验

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摘要

We sought to determine the response rate and toxicity profile of sequential paclitaxel and bryostatin-1, a novel, selective inhibitor of protein kinase C, in patients with advanced esophageal cancer.

机译：我们寻求确定顺序性紫杉醇和bryostatin-1（一种新型的选择性蛋白激酶C抑制剂）对晚期食管癌患者的反应率和毒性。

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来源
《Cancer Chemotherapy and Pharmacology 》 |2008年第5期| 875-880| 共6页
作者
Geoffrey Y. Ku; David H. Ilson; Lawrence H. Schwartz; Marinela Capanu; Eileen O’Reilly; Manish A. Shah; David P. Kelsen; Gary K. Schwartz;
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作者单位

Department of Medicine Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York NY 10021 USA;

Department of Medicine Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York NY 10021 USA;

Department of Radiology Memorial Sloan-Kettering Cancer Center New York USA;

Department of Biostatistics and Epidemiology Memorial Sloan-Kettering Cancer Center New York USA;

Department of Medicine Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York NY 10021 USA;

Department of Medicine Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York NY 10021 USA;

Department of Medicine Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York NY 10021 USA;

Department of Medicine Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York NY 10021 USA;

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正文语种 eng
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关键词
Bryostatin-1; Esophageal cancer; Gastroesophageal cancer; Paclitaxel; Protein kinase C;

机译：Bryostatin-1;食道癌;胃食道癌;紫杉醇;蛋白激酶C;

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专利

1. Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer. [J] . Ku GY, Ilson DH, Schwartz LH, Cancer chemotherapy and pharmacology. . 2008 ,第5期

机译：晚期食管癌患者序贯紫杉醇和bryostatin-1的1小时输注的II期试验。
2. A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma [J] . Jaffer A. Ajani, Yixing Jiang, Josephine Faust, Investigational New Drugs . 2006 ,第4期

机译：序贯紫杉醇和bryostatin-1（NSC 339555）在未经治疗的晚期胃或胃食管连接腺癌患者中的多中心II期研究
3. A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. [J] . Ajani JA, Jiang Y, Faust J, Investigational new drugs. . 2006 ,第4期

机译：序贯紫杉醇和bryostatin-1（NSC 339555）在未经治疗的晚期胃或胃食管交界性腺癌患者中进行的多中心II期研究。
4. Phase I/II clinical trials on the effect of weekly paclitaxel (wPTX) and wPTX containing combination regimens for advanced and metastatic gastric cancer -ECRIN group studies [C] . Sakamoto J, Kodera Y, Kobayashi M, International Gastric Cancer Congress . 2009

机译：I / II期临床试验关于每周紫杉醇（WPTX）和WPTX含有晚期和转移性胃癌组合方案的临床试验 - 分泌组研究
5. Communication preferences, expectations of benefit, and symptom burdens among advanced cancer patients and partners during patient participation in phase I trials [D] . Hlubocky, Fay J. 2010

机译：患者参加I期试验期间，晚期癌症患者及其伴侣之间的沟通偏好，受益期望以及症状负担
6. Assessment of Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line chemotherapy in patients with advanced HER-2 negative gastric or gastroesophageal junction cancers: the ARMANI phase III trial [O] . Maria Di Bartolomeo, Monica Niger, Federica Morano, 2019

机译：晚期HER-2阴性胃或胃食管连接癌患者接受雷莫昔单抗加紫杉醇作为转用维持与一线化疗继续的评估：ARMANI III期试验
7. Phase I-II trial of prolonged gemcitabine infusion plus paclitaxel as a biweekly schedule for advanced breast cancer patients pretreated with anthracyclines [O] . Vici, Patrizia, Fabi, Alessandra, Metro, Giulio, 2010

机译：I-II期延长吉西他滨输注紫杉醇作为蒽环类药物预处理的晚期乳腺癌患者的双周时间表

Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer

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