中医药序贯治疗模式和巩固治疗模式对 III/IV 期胃癌患者总生存和中位生存期的影响

摘要

目的：探讨中医药序贯治疗模式和巩固治疗模式对 III /IV 期胃癌患者总生存期和中位生存期的临床影响。方法：选择于2009年3月至2010年9月在我院治疗的72例经临床诊断为 III /IV 期胃癌的患者，采用随机数字表法将其分为治疗组和对照组各36例，其中给予治疗组患者中医药序贯治疗模式，对照组给予中医药巩固治疗模式，对比患者在接受治疗后总生存和中位生存期情况。结果：治疗组中位 OS 为32个月，明显优于对照组的19个月，2组比较有统计学意义（P ＜0.05），早期服用中药汤剂的患者中位 OS 为24.1个月，明显优于服用较晚患者的14.3个月，比较亦有统计学意义（P ＜0.05）；治疗组的 MST 为17.2个月，明显优于对照组的6.9个月，2组比较亦有统计学意义（P ＜0.05）。结论：虽中西医结合治疗胃癌可有效延长患者生存期，但中医药序贯治疗模式较巩固治疗模式而言，能更加有较的延长患者生存期，值得进一步推广应用。%Objective:To investigate the effect of Chinese medicine sequential treatment patterns and consolidation therapy patterns on overall survival time and median survival time of patients with stage III /IV gastric cancer.Methods:Seventy two patients who were di-agnosed as stage III /IV gastric cancer and received treatment in March 2009 to September 2010 in our hospital were randomly divided in-to treatment group (n =36)and control group (n =36).Patients in the treatment group were given sequential TCM treatment and pa-tients in the control group received consolidation TCMtherapy.The overall survival after treatment and median survival situation were ob-served.Results:The median OS of the treatment group was 32 months,which was significantly better than the 19 months of the control group (P <0.05);the median OS of patients who took decoction in early stage was 24.1 months,which was significantly better than the 14.3 months of those took decoction later,and there was statistically significant difference (P <0.05);MST of treatment group was 17. 2 months,which was significantly better than the 6.9 months in the control group,and the difference was also statistically significant (P<0.05).Conclusion:Although the combination therapy may prolong survival in gastric cancer patients,but sequential treatment of can better prolong the survival of patients,and therefore it is worthy of further applications.