Phase I dose-escalation study of vinflunine hard capsules administered twice a day for 2 consecutive days every week in patients with advanced/metastatic solid tumors

E. Calvo; J. B. Vermorken; S. Hiret; J. Rodon; J. Cortes; H. Senellart; J. Van den Brande; J. Dyck; A. Pétain; P. Ferre

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Phase I dose-escalation study of vinflunine hard capsules administered twice a day for 2 consecutive days every week in patients with advanced/metastatic solid tumors

机译：晚期/转移性实体瘤患者每周两次连续2天每天两次服用长春氟宁硬胶囊的I期剂量递增研究

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Background Vinflunine is a new microtubule inhibitor of the vinca-alkaloid family. It is marketed in transitional cell carcinoma of urothelial tract as a 20 min infusion given every 3 weeks in Europe.

机译：背景长春氟宁是长春花生物碱家族的新型微管抑制剂。它在欧洲每3周输注一次20分钟的输尿管上皮移行细胞癌。

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《Cancer Chemotherapy and Pharmacology》 |2012年第6期|p.1467-1475|共9页
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E. Calvo; J. B. Vermorken; S. Hiret; J. Rodon; J. Cortes; H. Senellart; J. Van den Brande; J. Dyck; A. Pétain; P. Ferre;
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1. Phase i dose-escalation study of vinflunine hard capsules administered twice a day for 2 consecutive days every week in patients with advanced/metastatic solid tumors [J] . CalvoE., VermorkenJ.B., HiretS., Cancer chemotherapy and pharmacology. . 2012,第6期

机译：在晚期/转移性实体瘤患者中，每天两次连续两天每天服用两次长春氟宁硬胶囊的I期剂量递增研究
2. Phase I dose-escalation study of oral vinflunine administered once daily for 6 weeks every 8 weeks in patients with advanced/metastatic solid tumours. [J] . J P Delord, J M Tourani, F Lefresne, Cancer chemotherapy and pharmacology. . 2013,第3期

机译：在患有晚期/转移性实体瘤的患者中，口服长春氟宁的I期剂量递增研究每8周每天一次，连续6周。
3. Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors [J] . Khanh Do, Giovanna Speranza, Lun-Ching Chang, Investigational New Drugs . 2015,第4期

机译：I期研究热休克蛋白90（Hsp90）抑制剂onalespib（AT13387）在患有晚期实体瘤的患者中每天连续2天每天给药一次
4. Midazolam Administered to 8-Day-Old Mouse Pups for Three Weeks Induces Cerebellar Cortex Alterations [C] . Maria Cristina Marquez-Orozco, Maria Veronica Gazca-Ramfrez, Graciela de la Fuente-Juarez and Amalia Marquez-Orozco Western Pharmacology Society . 2009

机译：Midazolam给8天龄小鼠幼犬施用三周，诱导小脑皮质改变
5. A phase I study of vincristine, escalating doses of irinotecan, temozolomide and bevacizumab (VIT-B) in pediatric and adolescent patients with recurrent or refractory solid tumors of non-hematopoietic origin [D] . Venkatramani, Rajkumar. 2010

机译：长春新碱，伊非替康，替莫唑胺和贝伐单抗（VIT-B）逐步剂量在患有非造血源性复发或难治性实体瘤的儿童和青少年患者中的I期研究
6. A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-hour Infusion With and Without G-CSF in a 14-day Cycle in Patients with Advanced Solid Tumors [O] . Roger B. Cohen, Suzanne F. Jones, Charu Aggarwal, -1

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机译：DANUSERTIB（PHA-739358）的I剂量升级研究在晚期固体肿瘤患者的14天循环中施用24小时输注和没有粒细胞菌落刺激因子

Phase I dose-escalation study of vinflunine hard capsules administered twice a day for 2 consecutive days every week in patients with advanced/metastatic solid tumors

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