OPN gene polymorphisms are associated with susceptibility and clinicopatholigical characteristics of cervical cancer in a Chinese cohort

摘要

Aim: To explore the possible association between Osteopontin (OPN) genetic polymorphisms and cervical cancer risk,nwhich remains undocumented yet.nMethod: We enrolled 300 patients with histologically confirmed cervical squamous cell carcinoma and 774 age-matched healthy,nunrelated, cancer-free female healthy subjects as control subjects. Three OPN gene polymorphisms were determined.nReulsts: The genotype distributions and allele frequencies of −156 GG/G and −443 T/C polymorphisms were significantlyndiffered between cervical cancer patients and controls. The cervical cancer cases had markedly higher percentage of −156 GGncarriage and significantly lower TT and TC of −443 genotypes than controls. The Logistic regression analysis showed that then−156 GG carriage was associated with significantly elevated OR of 2.492 for cervical cancer while the TT and TC of −443nrepresented lower risks. This trend was not seen in subjects without human papillomavirus infections. In addition, the −156 GGncarriages was significantly associated with poorer clinical conditions, including higher clinical stage, poorer tumor differentiation,nhigher positive lymph node status and higher chance of parametrical invasion. The −443 T/C and −66 T/G polymorphisms didnnot show any association with the clinicopathological feature.nConclusion: These results suggest that the −156 GG/G and −443T/C polymorphisms might be used as a genetic marker forncervical cancer susceptibility.