Study on the Effect of Isouramil on Some Pharmacological Responses with Special References to its Thermoregulatory Effects in Rats

摘要

Isouramil (IU) is an active aglycone of the glycoside convicine isolated from broad beans (Vicia Faba) with the capacity to autoxidize and generates hydrogen peroxide. The effect of successive reported doses (1.2 mg/100g body weight) equivalent to 1/10 LD_(50) of Isouramil in rats for two weeks on body temperature, hematology, some constituents of urine and blood glutathione were studied in male Sprague Dawely rats. There was a marked decrease in skin and tail temperatures but little effect on rectal temperature. Erythrocytes decreased (P < 0.05) after the second week of injection and haematocrite value increased (P < 0.01) after both first and second weeks. Creatinine and haemoglobin levels in urine were significantly increased (p < 0.05), while uric acid was not affected. Blood glutathione showed a significant (p < 0.01) decrease after 2 hours of injection and still depleted all over the period of experiment.