Sodium Sulfite Enhances Rhinovirus-Induced Chemokine Production in Airway Epithelial Cells

摘要

We investigated the effects of sodium sulfite (Na₂SO₃) on rhinovirus (RV)-induced chemokine production in A549 airway epithelial cells. Our results demonstrated that the treatment of A549 cells with 2,500 μM Na₂SO₃ enhanced the mRNA expression of RV-induced interleukin (IL)-8 1.8 fold (p = 0.025); and regulated on activation, normal T cell expressed and secreted (RANTES), 2.9 fold (p = 0.025). Moreover, the secretion of IL-8, RANTES, and interferon-γ-inducible protein (IP)-10 was increased in a statistically significant manner without affecting cell viability and RV replication. Our results suggest that Na₂SO₃ may potentiate RV infection by enhancing chemokine production.