bFGF and TGFβ expression in rat kidneys after ischemic/ reperfusional gut injury and its relationship with tissue repair

摘要

Intestinal ischemia/ reperfusion (I/R) occur commonly in critically ill patients. It is well recognized that gut I/R may cause tissue damage and dysfunction of intestine, and induce remote organ injury including kidney, lung, and liver. It may also lead to complications after severe burn or injury. Previous studies have focused on cellular elements, cytokines and inflammatory mediators. Relatively little attention has been paid endogenous Protective mechanisms, i.e. the growth factors.