Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2

摘要

Development of drug-resistance to chemotherapy and subsequent metastasis of tumor are primarily responsible for treatment failure and the death from cancer. There have been many previous studies on the relationship between expression of multidrug resistance (MDR) phenotype P-glycoprotein (P-gp) and the malignant properties of tumors, but the results are often conflicting~[1-8]. The difference in tumor types or MDR phenotype induced by specific agents might account for this discrepancy.