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Cyclooxygenase-2 expression and angiogenesis in colorectal cancer

机译:大肠癌中环氧合酶-2的表达与血管生成

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AIM: Cyclooxygenase-2 is involved in a variety of important cellular functions, including cell growth and differentiation, cancer cell motility and invasion, angiogenesis and immune function. However, the role of cyclooxygenase-2 as an angiogenic factor in colorectal cancer tissue is still unclear. We investigated the relationship between cyclooxygenase-2 and angiogenesis by analyzing the expression of cyclooxygenase-2 in colorectal cancer tissue, as well as its association with vascular endothelial growth factor (VEGF) and microvascular density (MVD). METHODS: The expression of cyclooxygenase-2, VEGF, as well as MVD was detected in 128 cases of colorectal cancer by immunohistochemical staining. The relationship between the cydooxygenase-2 and VEGF expression and MVD was evaluated. Our objective was to determine the effect of cyclooxygenase-2 on the angiogenesis of colorectal cancer tissue. RESULTS: Among 128 cases of colorectal cancer, 87 were positive for cyclooxygenase-2 (67.9%), and 49 for VEGF (38.3%), respectively. The microvessel counts ranged from 23 to 142, with a mean of 51.7 (standard deviation, 19.8). The expression of cyclooxygenase-2 was correlated significantly with the depth of invasion, stage of disease, metastasis (lymph node and liver), VEGF expression and MVD. Patients in T3-T4, stage Ⅲ-Ⅳ and with metastasis had much higher expression of cydooxygenase-2 than patients in T1-T2, stage Ⅰ-Ⅱ and without metastasis (P<0.05). The positive expression rate of VEGF (81.6%) in the cyclooxygenase-2 positive group was higher than that in the cyclooxygenase-2 negative group (18.4%, P<0.05). Also, the microvessel count (56+-16) in cyclooxygenase-2 positive group was significantly higher than that in cyclooxygenase-2 negative group (43+-12, P<0.05). The microvessel count in tumors with positive cyclooxygenase-2 and VEGF was the highest (60+-18, 41-142, P<0.05), whereas that in tumors with negative cyclooxygenase-2 and VEGF was the lowest (39+-16, 23-68, P<0.05). CONCLUSION: Cyclooxygenase-2 may be associated with tumor progression by madulating the angiogenesis in colorectal cancer tissue and used as a possible biomarker.
机译:目的:环氧合酶-2参与多种重要的细胞功能,包括细胞生长和分化,癌细胞的运动性和侵袭性,血管生成和免疫功能。然而,在大肠癌组织中环氧合酶2作为血管生成因子的作用仍不清楚。我们通过分析大肠癌组织中环氧合酶-2的表达及其与血管内皮生长因子(VEGF)和微血管密度(MVD)的关系,研究了环氧合酶-2与血管生成之间的关系。方法:采用免疫组织化学方法检测128例大肠癌组织中环氧合酶-2,VEGF和MVD的表达。评估了cydoxygenase-2和VEGF表达与MVD之间的关系。我们的目标是确定环氧合酶2对大肠癌组织血管生成的影响。结果:在128例大肠癌中,环氧合酶-2阳性的占87例(67.9%),而VEGF阳性的49例(38.3%)。微血管计数范围从23到142,平均值为51.7(标准偏差为19.8)。 COX-2的表达与浸润深度,病程,转移(淋巴结和肝),VEGF表达和MVD显着相关。 T3-T4,Ⅲ-Ⅳ期,有转移的患者比第T1-T2,Ⅰ-Ⅱ期,无转移的患者的环氧合酶-2表达高得多(P <0.05)。环氧合酶-2阳性组的VEGF阳性表达率(81.6%)高于环氧合酶-2阴性组(18.4%,P <0.05)。另外,环氧合酶-2阳性组的微血管计数(56 + -16)明显高于环氧合酶-2阴性组(43 + -12,P <0.05)。环氧合酶2和VEGF阳性的肿瘤的微血管计数最高(60 + -18,41-142,P <0.05),环氧合酶2和VEGF阴性的肿瘤的微血管计数最低(39 + -16, 23-68,P <0.05)。结论:环氧合酶-2可能通过调节大肠癌组织中的血管生成而与肿瘤的进展有关,并可能用作生物标志物。

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