Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort

摘要

Exposures in utero may increase the risk of type 2 diabetes. We tested the hypothesis that maternal smoking during pregnancy increases both the risk of early onset type 2 diabetes and non-diabetic obesity in offspring. Methods and results. We used data are from the British National Child Development Study (NCDS), based on the Perinatal Mortality Survey (PMS) of about 17 000 births from 3 to 9 March 1958. The first sweep of the study in 1965 had 15 396 responses. The cohort remained generally representative at age 33 years (n=11 359). Missing data reduced the proportion in social class V from 6.4% in sweep 1 to 5.3%. Ethics committee approval was obtained for research involving medical examinations, and cohort members signed consent forms at age 33 years allowing access to medical records.