The interaction of general anaesthetics with recombinant GABA_A and glycine receptors expressed in Xenopus laevis oocytes: a comparative study

摘要

The data demonstrate a variety of intravenous general anaesthetic agents, at clinically relevant concentrations, to augment preferentially GABA-evoked currents mediated by the α_1β_1γ_2L receptor subunit combination as compared to their effects on both α_1 and α_1β glycine receptors. However, the presence on glycine receptors of lower affinity modulatory binding sites for pentobarbitone, propofol and trichloroethanol may aid in the identification of the molecular determinants of the CNS actions of these anaesthetics.