Nitric oxide-dependent and -independent vascular hyporeactivity in mesenteric arteries of portal hypertensive rats

摘要

These data indicate that both NO-dependent and NO-independent mechanisms are involved in the vasoconstrictor hyporesponsiveness of mesenteric arteries from portal hypertensive rats. The hyporeactivity to AVP and ET-1 is mediated by NO-independent. AVP and ET-1, in addition, seem to inhibit the NO-independent mechanism of vascular hyporeactivity, since the hyporesponsiveness to METH was reduced in the presence of AVP or ET-1 and abolished by the combination of these peptides with L_ NAME.