Synergistic interaction between endothelium-derived NO and prostacyclin in pulmonary artery: potential role for K~_ATP channels

摘要

The synergistic interaction between endothelium-derived NO and PGI_2 in canine pulmonary artery is mediated by activation of K~_ATP channels, presumably by an endothelium-derived hyperpolarizing factor (EDHF). The pattern of endothelial dilator mediators and the presence of this synergistic interaction is dependent on the nature of the endothelial stimulus.