Contribution of α-adrenoceptors to depolarization and contraction evoked by continuous asynchronous sympathetic nerve activity in rat tail artery

摘要

We conclude that the constriction of the tail artery induced by CTX-1, which mimics the natural discharge of postganglionic perivascular axons, is due almost entirely toα-adrenoceptor activation. The results indicate that neuronally released noradrenaline activates more than one α-adrenoceptors subtype. The depolarization is dependent primarily on α_2-adrenoceptor activation.