Inhibition of glycine currents by dextromethorphan in neurones dissociated from the guinea-pig nucleus tractus solitarii

摘要

The results indicate that DM inhibits I_Gly in single neurones of NTS, and further suggest that DM at a low concentration may act on the glycine receptor-ionophore complex, but not on the Cl~- channel of the complex. However, a relatively high concentration of DM may at least partly affect the Cl~- channel of the complex.