Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways

摘要

Lipopolysaccharide(LPS) is implicated in many pulmonary and airway inflammatory diseases. Tachykinins released from nerve endings increase vascular permeability. In this study, we have assessed The enhancement by LPS of tachykinin-mediated plasma exudation in guinea-pig airways, and examined The role of oxidants as well as leukocyte adherence. LPS (100 μg kg~-1, i.v.) was administered 0-3 h before bilateral electrical stimulation of the cervical Vagus nerves in animals anaesthetized with urethane and ventilated. Vagal stimulation increased vascular Permeability in the airways. LPS enhanced the vagally-mediated plasma exudation with the peak effect at 1 h after LPS administration.