ATP-sensitive K~+ channels in smooth muscle cells of guinea-pig mesenteric lymphatics: role in nitric oxide and β-adrenoceptor agonist-induced hyperpolarizations

摘要

Intracellular microelectrode recordings were performed to investigate the membrane K~`+ conductances involved in smooth muscle hyperpolarization of lymphatic vessels in the guinea-pig mesentery. Nitric oxide(NO), released either by the endothelium after acetylcholine(ACh; 10μM) stimulation or By sodium nitroprusside (SNP; 50-100　μM), hyperpolarized lymphatic smooth muscle. These responses Were inhibited with the guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one (ODQ, 10μM).