Potent inhibition of both the acute and delayed emetic responses to cisplatin in piglets treated with GR205171, a novel highly selective tachykinin NK_1 receptor antagonist

摘要

The effects of GR205171, a selective tachykinin NK_1 receptor antagonist, were investigated on both the acute and delayed phases of cisplatin-induced nausea-like behaviour and vomiting in the conscious piglet. Animals receiving cisplatin(5.5 mg kg~-1, i.v.) were observed for 60 h. Fifteen min prior to cisplatin Infusion(TO_15min), eight piglets acting as controls received an intravenous injection of saline solution (1 ml kg~-1), whereas experimental animals received a single i.v. administration of GR205171 (1 kl kg~-1) at a dose of 0.01 (n =8), 0.03(n =8), 0.1(n=8), 0.3 (n=16) or 1.0 (n =13) mg kg~-1.